Beijing Key Lab of Magnetic Resonance Imaging Device and Technique

The Key Laboratory of Magnetic Resonance Imaging (MRI) Equipment and Technology was established in 2000, based on the 985 Clinical Multidisciplinary Center Project of Peking University, jointly constructed by Beihai Medical College and the Department of Medical Physics of the Faculty of Medicine of Peking University, which was recognized by Beijing Municipality as a key laboratory of Beijing Municipality in 2011. The laboratory takes the research and development of new medical imaging technology as its main research direction, focusing on the research and development of new technologies and new instruments, and exploring new methods of diagnosis and treatment of diseases. Under the leadership of Prof. Han Hongbin, the director of the laboratory, together with experts from the School of Engineering, School of Information Science and Technology, and School of Mathematics of Peking University, the laboratory was successfully approved as the qualification for the construction of the first-level discipline of medical technology by the Ministry of Education of China, and the Institute of Medical Technology of Peking University Medical Faculty was established with the support of the Ministry of Medicine. Since 2005, relying on the interdisciplinary team, it has made breakthroughs in the method of brain cell outer gap imaging analysis, and relying on the new method, it has made a series of breakthroughs in the brain structure, the mechanism of occurrence and development of brain diseases and new treatment methods, and has made achievements in the research and development of innovative technologies, academic development, interdisciplinary talent training, and team building.

I. Laboratory research direction and main achievements: establish new imaging analysis methods, decipher the unknown structural space in the brain, and open up a new direction for the diagnosis and treatment of brain diseases: Prof. Han Hongbin, director of the laboratory and academic leader, proposes and establishes in vivo nano-scaled ultrastructural imaging analysis methods and instrumentation, and carries out a series of deciphering of the brain's extracellular space, which reveals the brain lymphatic fluid drainage law, and discovers and confirms the structural basis of the new partitioned structural system in the brain, and puts forward the hypothesis of the brain partitioned homeostasis theory. On the basis of this work, we have invented a new theory and method for the treatment of brain diseases via the extracellular space, and solved the international problem that the blood-brain barrier prevents drugs from entering the brain. We have further developed a new precise delivery system for brain diseases, which is more efficient, safer, and less toxic than the international patented technology, and has been approved as an international invention patent. The research methodology was published as a cover story in “progress in neurobiology” and “agingand disease”. Invented a series of methods to actively regulate the transport of substances in the ECS, and proposed a new mechanism and a new theory for the treatment of AD by red light nanoparticles, which was published as a featured article in Alzheimer's & Dementia: Translational Research & Clinical Interventions, and was supported by the National Outstanding Young People's Foundation of China, the National Natural Science Foundation of China, and the National Key Project for Major Instruments. His research has been supported by the National Youth Excellence Foundation of China, the National Natural Science Foundation of China, and the Major Instrumentation Program of China. His research results won the first prize of Huaxia Medical Science and Technology Award, the 2018 Capital Science and Technology Leading Talent Cultivation Project, the first Capital Science and Technology Innovation Achievement Exhibition Outstanding Projects, and was selected as one of the top ten medical science and technology news in 2019. He has organized two consecutive Peking University Annual International Neuroscience Conferences, and visited the University of London and the University of Cambridge to publicize the new discoveries and detection technologies of the brain cell microenvironment, and established a cooperative relationship with the University of London to carry out international cooperation.

II. Team building and talent training: around the brain imaging new methods and new technology esearch, the laboratory set up more than 30 interdisciplinary team of experts from mathematics, chemistry, physics, medicine, neurobiology, pharmacy, informatics. 2019, in the direction of the chemical synthesis of signal sources for brain imaging analysis technology to cultivate a National Outstanding Young Foundation recipients, the introduction of the direction of the information and computer superior youth 1; relying on interdisciplinary team, after more than 10 years of preparation, the laboratory successfully approved the Ministry of Education of the first discipline of medical technology doctoral point construction qualification, the establishment of the first Peking University Medical Technology Degree Chapter and the Institute of Medical Technology of Peking University Department of Medicine, the director of the laboratory is the chairman of the subcommittee. team, after more than 10 years of preparation, in 2018 was successfully approved by the Ministry of Education of the first-level disciplines of medical technology doctoral program construction qualification, the establishment of any first Peking University Medical Technology Degree Sub-Committee and Peking University Medical Research Institute of Medical Technology, the laboratory director as the chairman of the sub-committee and the executive vice president of the Institute of Medical Technology, medical physics, five faculty members to join the laboratory construction, to lay the foundation for the future of the discipline of medical technology and the research and development of new technologies. Laying the foundation for future medical technology discipline and new technology research and development.

III. Future goals: In the next five years, the laboratory will establish an international leading in vivo brain cell microenvironmental imaging detection and analysis platform, take the lead in the construction and development of Peking University's medical technology disciplines, and build the laboratory into a world-class in vivo cellular microenvironmental detection and imaging scientific research and technical service platform. Based on this platform, the laboratory will join hands with basic, clinical and scientific research and development teams to develop the theory of cellular microenvironment, fill the loopholes of “cellular theory”, provide theoretical and technical support for the development of emerging health industries, improve the international competitiveness of China's large-scale medical equipments and technologies, and build a first-class discipline of medical technology in the world.

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Laboratory (Center) Director: Han Hongbin Laboratory (Center) Academic Committee Director: Feng Yizhi

Laboratory Contact: Mr. Lu Guest Tel: 010-82266972