Dr. Xiaolong Liang is a Principal Investigator and Doctoral Supervisor at Peking University Third Hospital, the Recipient of National Science Fund for Excellent Young Scholars, Beijing Outstanding Young Scientist Program, and Beijing Top Young Talents Program. He currently chairs the Biomedical Imaging Technology Branch of the China Medicinal Biotechnology Association and serves as Deputy Director of the Ultrasound Molecular Imaging Committee at the Chinese Society of Ultrasound in Medicine and Engineering. His multidisciplinary leadership extends through executive roles in the Youth Council of Chinese Anti-Cancer Association, Youth Committee Member of Nano-Oncology Committee of Chinese Anti-Cancer Association, Youth Committee Member of Experimental Medicine Committee of the National Health Industry Enterprise Management Association, Youth Committee Member of Biomedical Photonics Branch of the Chinese Society of Biomedical Engineering, and Committee Member of Ultrasound Medicine Innovation and Development Management Branch of Guangdong Medical Industry Association. He is the Editorial Board Member of  Chinese Journal of Medical Imaging Technology  and  Chinese Medicinal Biotechnology , Youth Editorial Board Member of  Advanced Ultrasound in Diagnosis and Therapy . He obtained Ph.D. from Harbin Institute of Technology in 2012 and conducted postdoctoral research at Peking University School of Engineering and Institute of Biophysics, Chinese Academy of Sciences. As founding director of the Ultrasound Medicine and Molecular Imaging Laboratory at Peking University Third Hospital in 2015, Dr. Liang spearheads translational research in medical ultrasound, molecular imaging, and minimally invasive therapy technologies. He has published 50+ SCI papers as first/corresponding author in  Nature Communications ,  Advanced Materials ,  ACS Nano ,  Advanced Functional Materials , and  Biomaterials . He has also authorized 20+ invention patents.

Research Directions:

1. Ultrasound Medicine: Integrating ultrasound with medical applications to develop ultrasound contrast agents for precision diagnosis and targeted therapy.

2. Molecular Imaging: Designing molecular imaging probes for rapid, stable, high-sensitivity, and high-specificity  in vivo  imaging.

3. Minimally Invasive Therapy: Developing therapeutic materials and drug delivery systems based on light, sound, magnetic, electric, and thermal technologies.

Education and Work Experience:

1) Education experience

2008.9-2012.1, Harbin Institute of Technology, Biomedical Engineering, PhD

2005.9-2008.7, Guangxi Normal University, Master of Organic Chemistry

2001.9-2005.7, Zhanjiang Normal University, Chemistry, Bachelor

2) Research and academic work experience

2015.8-present, Principal Investigator at Peking University Third Hospital

2014.7-2015.7, Associate Researcher, Key Laboratory of Interdisciplinary Science, Institute of Biophysics, Chinese Academy of Sciences

2012.4-2014.6, Postdoctoral Fellow, Department of Biomedical Engineering, Peking University

Research Projects:

National Natural Science Foundation of China, General Program, "Ultrasound-Enhanced Functionalized Silicasome for Immunotherapy", 2023-01-01 to 2026-12-31, PI;

Beijing Natural Science Foundation, Outstanding Youth Program, "Piezoelectric Ultrasound for Enhanced Tumor Immunotherapy", 2022-10 to 2025-12, PI;

NSFC, Excellent Young Scholars Program, "Ultrasound-Enhanced Nanodrug Delivery System for Tumors", 2019-01-01 to 2021-12-31, PI;

NSFC, General Program, "Ultrasound Microbubble-Mediated Sonodynamic/Gene Therapy in Cancer", 2018-01-01 to 2021-12-31, PI;

NSFC, General Program, "Thermochemotherapy with Targeted Multifunctional Silicasomes", 2016-01-01 to 2019-12-31, PI

Professional Affiliations:

Chairman, Biomedical Imaging Technology Branch, China Medicinal Biotechnology Association

Vice Chairman, Ultrasound Molecular Imaging Committee, Chinese Society of Ultrasound in Medicine and Engineering

Standing Council Member, Youth Committee, Chinese Anti-Cancer Association;Youth Committee Member, Biomedical Photonics Branch, Chinese Society of Biomedical Engineering

Youth Committee Member, Nano-Oncology Committee, Chinese Anti-Cancer Association

Youth Committee Member, Experimental Medicine Committee, National Health Industry Enterprise Management Association

Youth Committee Member, Nanotechnology Committee, Chinese Pharmaceutical Association

Youth Committee Member, Interventional Medical Engineering Committee, Chinese Medical Doctor Association

Committee Member, Ultrasound Medicine Innovation and Development Management Branch, Guangdong Medical Industry Association

Representative Publications:

Qingshuang Tang, Suhui Sun, Ping Wang, Lihong Sun, Yuan Wang, Lulu Zhang, Menghong Xu, Jing Chen, Ruiqi Wu, Jinxia Zhang, Ming Gong, Qingfeng Chen, Xiaolong Liang*. Genetically Engineering Cell Membrane-Coated BTO Nanoparticles for MMP2-Activated Piezocatalysis-Immunotherapy. Adv Mater., 2023, 35(18): e2300964.

Yuan Wang^#, Qingshuang Tang#, Ruiqi Wu, Suhui Sun, Jinxia Zhang, Jing Chen, Ming Gong, Chaoyi Chen, Xiaolong Liang*. Ultrasound-Triggered Piezocatalysis for Selectively Controlled NO Gas and Chemodrug Release to Enhance Drug Penetration in Pancreatic Cancer. ACS Nano, 2023, 17, 3557-3573.

Jing Chen, Qingshuang Tang, Yuan Wang, Menghong Xu, Suhui Sun, Jinxia Zhang, Ruiqi Wu, Xiuli Yue, Xiaoda Li, Qingfeng Chen, Xiaolong Liang*. Ultrasound-Induced Piezocatalysis Triggered NO Generation for Enhanced Hypoxic Tumor Therapy. ACS Appl Mater Interfaces, 2023, 15, 15220-15234.

Duo Zhao, Menghong Xu, Siyuan Yang, Huide Ma, Huiwen Li, Rong Wu, Yu He, Shuming Wang*, Xiaolong Liang*. Specific diagnosis of lymph node micrometastasis in breast cancer by targeting activatable near-infrared fluorescence imaging. Biomaterials, 2022, 282, 121388.

Suhui Sun, Qingshuang Tang, Yuan Wang, Lulu Zhang, Jing Chen, Menghong Xu, Lihong Sun, Ligang Cui, Xiaolong Liang*. In Situ Micro-Nano Conversion Augmented Tumor-Localized Immunochemotherapy. ACS Appl. Mater. Interfaces, 2022, 14, 27013-27027.

Xiaotu Ma, Meinan Yao, Yu Gao, Yale Yue, Yao Li, Tianjiao Zhang, Guangjun Nie, Xiao Zhao*, Xiaolong Liang*. Functional Immune Cell-Derived Exosomes Engineered for the Trilogy of Radiotherapy Sensitization. Adv Sci (Weinh). 2022, 9(23): e2106031.

Chaoyi Chen, Yuwen Chen, Lulu Zhang, Xuanhao Wang, Qingshuang Tang, Yan Luo, Yuan Wang, Cheng Ma*, Xiaolong Liang*. Dual-targeting nanozyme for tumor activatable photo-chemodynamic theranostics. J Nanobiotechnology, 2022, 20(1): 466.

Xiaoqing Ren#, Wanqiong Yuan#, Jing Ma, Ping Wang, Suhui Sun, Shumin Wang, Rongsheng Zhao*, Xiaolong Liang*. Magnetic nanocluster-mediated photothermal effect and macrophage modulation for synergistic photothermal immunotherapy of cancer. Biomater Sci. 2022, 10(12): 3188-3200.

Ping Wang, Lihong Sun, Menghong Xu, Suhui Sun, Lulu Zhang, Jinxia Zhang, Shumin Wang, Xiaolong Liang*. Titania/iron oxide nanoplatform operates as hydrogen peroxide enriched vector for amplification of fenton catalytic efficiency in cancer theranostics. Chemical Engineering Journal, 2021, 418, 129381.

Ping Wang, Qingshuang Tang, Lulu Zhang, Menghong Xu, Lihong Sun, Suhui Sun, Jinxia Zhang, Shumin Wang, Xiaolong Liang*. Ultrasmall Barium Titanate Nanoparticles for Highly Efficient Hypoxic Tumor Therapy via Ultrasound Triggered Piezocatalysis and Water Splitting. ACS Nano. 2021, 15(7): 11326-11340.